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Are Low Cholesterol Levels Bad For Your Health?

High Cholesterol, Low Cholesterol - Lipid Levels Are Best At Middle Ground

By Maureen Salamon

Updated October 04, 2008

(LifeWire) -
There's so much talk about the dangers of high cholesterol, but can low cholesterol levels be equally bad?

Healthy cholesterol levels seem to follow one of life's major rules: Avoid extremes.

Cholesterol levels can fall within one of three ranges. For adults, normal cholesterol levels are between 140 and 200 milligrams per deciliter (mg/dL). Total cholesterol levels above 240 mg/dL are considered high, and levels below 140 mg/dL are considered unusually low, although many perfectly healthy people have levels in this range.

High total cholesterol levels are bad -- that is a no-brainer. Too much of this wax-like, fatty substance in the blood can lead to artery disease (atherosclerosis), heart disease, or stroke.

But compared to high cholesterol, low cholesterol is pretty much off most people's radars. While there is no question about the value of reducing high cholesterol as a strategy for preventing or treating heart disease, there is much less agreement on how (or whether) to respond to very low cholesterol levels.

Can cholesterol levels be too low? From the standpoint of heart health, probably not. On the other hand, unusually low levels of cholesterol could undermine the body in other areas, including the brain, liver, and digestive system.

But there is a chicken-and-egg aspect to this problem, which scientists have been sorting through for at least two decades. Sometimes low cholesterol causes harm; other times, it simply seems to be a result of an existing disease. It can provide benefits in one area and do harm in another.

For example, over a long period, very low cholesterol levels increase the odds of hemorrhagic stroke, which occurs when a blood vessel ruptures and bleeds into the brain. Such strokes are more likely in individuals with low cholesterol levels because blood with small amounts of cholesterol does not clot as easily. However, and ischemic stroke (which is far more prevalent) occurs when clots or other material blocks blood flow to the brain -- cholesterol is a major source of such blockages.

Cholesterol also plays a role in brain function. It appears that insufficient brain cholesterol hinders the action of serotonin, a chemical that carries messages between brain cells and that is closely associated with mood. Abnormally low cholesterol levels have been linked to depression and anxiety.

For other conditions, low cholesterol is more of a symptom than a cause. The liver produces about three-quarters of our body's cholesterol supply, with the remaining supply coming from diet, especially from meat, eggs, dairy and seafood. Not surprisingly, cholesterol levels can drop if the liver is compromised due to alcoholism, cancer, or another disease. Any serious disease of the gastrointestinal tract or malnutrition can also reduce cholesterol levels.

The Bottom Line

Cholesterol is absolutely essential to the body and is present in every cell. Without it, sex hormones would not be produced and food digestion could not take place.

The best plan of action is to keep total cholesterol within the middle range, somewhere between 150 and 200 mg/dL. Since high cholesterol is far more common than low, the best way to keep cholesterol levels within the normal range is to maintain healthy lifestyle choices: Eat plenty of fruits, vegetables, whole-grain breads and nuts; limit whole-fat foods, processed flours and sugars; and get plenty of exercise.

Sources: Gau, Gerald. "Cholesterol Level: Can It Be Too Low?." Mayo Clinic. 17 July 2006. Mayo Foundation for Medical Education and Research. 22 Feb 2008 <http://www.mayoclinic.com/health/cholesterol-level/AN01394>.

Moran, David T.. "Cholesterol Test." Diseases and Conditions Encyclopedia. 22 Sep 2006. Discovery Health. 25 Feb 2008 <http://health.discovery.com/encyclopedias/illnesses.html?article=1129>.

Broderick, J.P.. "Guidelines for the Management of Spontaneous Intracerebral Hemorrhage." Stroke 30(1999): 905-915.

"High Blood Cholesterol: What You Need to Know." National Heart, Lung and Blood Institute. June 2005 29 Feb 2008 <http://www.nhlbi.nih.gov/health/public/heart/chol/wyntk.htm>.

LifeWire, a part of The New York Times Company, provides original and syndicated online lifestyle content. Maureen Salamon is a freelance writer who has written for newspapers, websites and hospitals, as well as the Chicken Soup for the Soul book series. She is co-authoring the memoir of the pediatrician who discovered AIDS in children.

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