The researchers examined 1,214 men taking statins over a 16-year period. They found that after beginning statin therapy, the PSA levels decreased along with their cholesterol levels, especially LDL cholesterol.
As of now, the investigators of this study are not sure if the lowered LDL cholesterol decreases ones risk of prostate cancer or if prostate disease is still present despite lowered PSA levels. Taking a statin may help to lower cholesterol levels, but it could also reduce PSA levels, rendering it useless as a marker for prostate cancer. While more research in this area is needed, this finding may provide insight into the role that cholesterol may play in other areas of the body.
Source:
Hamilton RJ, Platz EA, Goldberg KC, Freedland SJ. The association between cholesterol and PSA. J Urol 2008; 179: 721 abstract 2094.

